Purpose — to comparatively evaluate the mechanical stability of the edge of central fragment of anterior lens capsule after manual and femtolaser capsulotomy. Material and methods. The mechanical tests were performed on the central fragments of the anterior lens capsules obtained intraoperatively after manual and femtolaser capsulotomy (15 and 13 samples, respectively). The conditions of the developed method of mechanical testing are as close to in vivo as possible. The method allows evaluation of the mechanical response mainly from the edge of the sample, reception of the averaged response from the four edges of the capsule, and almost eliminates the effect of additional edge notches in samples obtained by manual capsulotomy. Results. After manual capsulotomy, the maximum force and elongation of the anterior capsule sample at maximum tensile strength were significantly higher than similar characteristics of the samples after femtolaser capsulotomy. Conclusion. The obtained results correspond with the morphological studies of capsule edge structure after manual and femtolaser capsulotomy. The edge of the anterior capsule after femtolaser capsulotomy has form, in rough approximation, close to one of a postage stamp perforation, which is the consequence of micro-irregularities (microfractures) in the areas irradiated by pulsed laser, and wider area of deepithelization compared to the manual technique.