Role of molecular and genetic factors in survival from uveal melanoma

S.V. Saakian

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

A.Iu. Tsygankov

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

A.G. Amirian

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

N.V. Sklyarova

Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062

D.V. Zaletaev

Laboratoriia molekuliarnoĭ genetiki cheloveka NII molekuliarnoĭ meditsiny Pervogo moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Role of molecular and genetic factors in survival from uveal melanoma

Authors:

S.V. Saakian, A.Iu. Tsygankov, A.G. Amirian, N.V. Sklyarova, D.V. Zaletaev

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Journal: Vestnik Oftalmologii. 2016;132(1): 3‑9

DOI: 10.17116/oftalma201613213-9

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To cite this article:

Saakian SV, Tsygankov AIu, Amirian AG, Sklyarova NV, Zaletaev DV. Role of molecular and genetic factors in survival from uveal melanoma. Vestnik Oftalmologii. 2016;132(1):3‑9. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma201613213-9

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Aim — to analyze survival rates in uveal melanoma (UM) patients and establish correlations with chromosome 3 monosomy, chromosome 1p deletion, and RASSF1A methylation. Material and methods. Methylation-specific PCR analysis was performed in 104 patients with histologically verified UM. Results. A statistically significant correlation has been found between chromosome 3 monosomy, on the one hand, and mixed/epithelioid cell melanomas and ciliary body involvement, on the other. As for chromosome 1p deletion, it has demonstrated association with extrabulbar tumor growth. We have also calculated 5-year survival and mortality rates in «large» UMs and their relationship with chromosome 3 monosomy, chromosome 1p deletion, and RASSF1A methylation. Conclusion. Chromosome 3 monosomy is associated with lower survival rates, while RASSF1A methylation — with a better prognosis. A combination of molecular and genetic changes (particularly, chromosome 3 monosomy and chromosome 1p deletion) also leads to reduced survival in UM patients.

Keywords:

uveal melanoma

chromosome 3 monosomy

chromosome 1p deletion

RASSF1A methylation

survival rate

Authors:

S.V. Saakian

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

A.Iu. Tsygankov

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

A.G. Amirian

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

N.V. Sklyarova

Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062

D.V. Zaletaev

Laboratoriia molekuliarnoĭ genetiki cheloveka NII molekuliarnoĭ meditsiny Pervogo moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

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