Raman spectroscopy and its application in different areas of medicine

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The aim of the review is to learn about the areas of application of the Raman spectroscopy in medicine, particularly in dentistry. The method is widely used in biology, medicine, pharmacy, forensic science, gemology, food industry and other industries. The main advantages of Raman spectroscopy are no need for sample preparation and small amounts of the object of study, as well as the ability to contactlessly obtain unique information about the conformation and microenvironment of living cell molecules. The disadvantages are high costs of the equipment that are compensated with the long-term use by having no costs for additional reagents. The combinatorial scattering is used in dermatology, as it is a high-accuracy automated method of visualization and diagnostics of both benign growths as pigmented nevus, seborrheic keratosis, and malignant neoplasms as melanoma and basal cell carcinoma. This method is an analytical tool for diagnosing various diseases, making the direct measurements in hard and liquid media easier, does not require special treatment of samples and is not sensitive to absorption bands. The Raman spectroscopy use in dentistry allows diagnosing and comparative analysis of the changes of hard tissues of teeth and mucous membrane of the mouth, which improves security and rationalization of treatment and further prevention of complications before and after making different operations.

Keywords:

Raman spectroscopy

optical diagnostics

dentistry

teeth whitening

periodontal disease

Authors:

O.A. Magsumova

Samara State Medical University

ORCID: 0000-0002-0511-6550

V.A. Polkanova

Samara State Medical University

E.V. Timchenko

Samara National Research University

L.T. Volova

Samara State Medical University

Received:

29.04.2021

Accepted:

10.05.2021

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