Some features of cell-mediated immunity in patients with breast cancer undergoing breast implant reconstruction

O.I. Kit

National Medical Oncology Research Center

N.E. Manturova

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

SPIN RSCI: 5232-0412
Scopus AuthorID: 55461712100
ORCID: 0000-0003-4281-1947

V.Yu. Przhedetskaya

National Medical Oncology Research Center

A.B. Sagakyants

National Medical Research Centre of Oncology

E.Yu. Zlatnik

National Medical Research Centre of Oncology

V.I. Sharobaro

Federal Research and Clinical Center of Specialized types of Medical Care and Medical Technologies of FMBA of Russia

E.V. Verbo

Petrovsky Russian Research Center of Surgery;
National Medical Research Center for Dentistry, Oral and Maxillofacial Surgery

ORCID: 0000-0001-9843-5026

Yu.V. Przhedetsky

National Medical Research Center of Oncology

Some features of cell-mediated immunity in patients with breast cancer undergoing breast implant reconstruction

Authors:

O.I. Kit, N.E. Manturova, V.Yu. Przhedetskaya, A.B. Sagakyants, E.Yu. Zlatnik, V.I. Sharobaro, E.V. Verbo, Yu.V. Przhedetsky

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2022;(1): 22‑31

DOI: 10.17116/plast.hirurgia202201122

Downloaded: 73

To cite this article:

Kit OI, Manturova NE, Przhedetskaya VYu, Sagakyants AB, Zlatnik EYu, Sharobaro VI, Verbo EV, Przhedetsky YuV. Some features of cell-mediated immunity in patients with breast cancer undergoing breast implant reconstruction. Plastic Surgery and Aesthetic Medicine. 2022;(1):22‑31. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia202201122

Кардиологические дебаты — VI. Версия 2.0

Доказательная гастроэнтерология: pro et contra

Актуальные вопросы педиатрической практики

Использование инфографики авторами научных работ

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OBJECTIVE

To analyze the role of cell-mediated immunity in development of complications after breast reconstruction in patients with breast cancer.

MATERIAL AND METHODS

We studied cell-mediated immunity in wound and axillary fluid of 46 breast cancer patients within 7 days after implantation of a textured (TI) and polyurethane implant (PUI). Populations and subpopulations of immune cells were analyzed in peripheral blood and wound discharge using flow cytometry.

RESULTS

We found similar changes in cellular parameters for both implants. Higher content of cytotoxic CD8⁺-lymphocytes, NK-lymphocytes, and NKT-lymphocytes underlies development of scar tissue within the first postoperative week after TI implantation.

CONCLUSION

Regarding local immunity, TIs look more favorable compared to PUIs. PUI suppresses local immunity that can further increase the likelihood of local recurrence.

Keywords:

breast cancer

skin-sparing mastectomy

implants

capsular contracture

central and local cellular immunity

Authors:

O.I. Kit

National Medical Oncology Research Center

N.E. Manturova

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

SPIN RSCI: 5232-0412
Scopus AuthorID: 55461712100
ORCID: 0000-0003-4281-1947

V.Yu. Przhedetskaya

National Medical Oncology Research Center

A.B. Sagakyants

National Medical Research Centre of Oncology

E.Yu. Zlatnik

National Medical Research Centre of Oncology

V.I. Sharobaro

Federal Research and Clinical Center of Specialized types of Medical Care and Medical Technologies of FMBA of Russia

E.V. Verbo

Petrovsky Russian Research Center of Surgery;
National Medical Research Center for Dentistry, Oral and Maxillofacial Surgery

ORCID: 0000-0001-9843-5026

Yu.V. Przhedetsky

National Medical Research Center of Oncology

Received:

23.12.2021

Accepted:

10.01.2022

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