N.I. Kurysheva
Oftal'mologicheskij tsentr Federal'nogo mediko-biologicheskogo agentstva, ul. Gamalei, 15, Moskva, Rossijskaja Federatsija, 123098
L.V. Lepeshkina
Ophthalmological Center of the Federal Medical-Biological Agency of the Russian Federation, A.I. Burnazyan Federal Medical and Biophysical Center of FMBA, 15 Gamalei St., Moscow, Russian Federation, 123098
E.O. Shatalova
Clinics of doctor ShatalovA Naberezhnaja St., Orekhovo-Zuyevo, Russia
Comparative study of factors associated with the progression of primary open-angle and angle-closure glaucoma
Journal: Russian Annals of Ophthalmology. 2020;136(2): 64‑72
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To cite this article:
Kurysheva NI, Lepeshkina LV, Shatalova EO. Comparative study of factors associated with the progression of primary open-angle and angle-closure glaucoma. Russian Annals of Ophthalmology.
2020;136(2):64‑72. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma202013602164
Purpose — to compare the factors associated with the progression of primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). Material and methods. This prospective study analyses clinical data of POAG and PACG patients followed up for 6 years. The progression of glaucomatous optic neuropathy (GON) was determined using perimetry and spectral optical coherence tomography (OCT). The value of each diagnostic indicator (z-value) was calculated using the Wilcoxon—Mann—Whitney test and the area under the ROC-curve (AUC) to identify the parameters reliably associated with the progression in both groups of patients. Results. According to OCT, 47.3% of PACG patients and 52.46% of POAG patients had GON progressing, while according to perimetry, these figures were 21.8% and 23%, respectively. The common factors associated with progression of these glaucoma forms were age (AUC 0.7, z –1.9 in PACG and AUC 0.7, z –2.9 in POAG) and maximum IOP (0.7; –2.7 in PACG and 0.79; –5.4 in POAG). The progression of PACG is associated with lens size (0.7; –2.4), subfoveal choroidal thickness (AUC 0.8, z –3.3) and peripapillary choroidal thickness (0.79; –3.2), resistive index in the vortex veins (0.81; –3.3) and their end diastolic blood flow velocity (0.83; 3.2). The progression of POAG is associated with a thin peripapillary (0.75; 2.6) and subfoveal choroid (0.74; 2.5), increased resistive index in the posterior short ciliary arteries (0.8; –2.3), and initial retinal nerve fiber layer (RNFL) thickness: 0.69; 2.9. Conclusion. The progression of POAG and PACG has only two common factors — age and maximum IOP. The progression of PACG is mainly related to the lens size, venous dysfunction and the choroid expansion, while the progression of POAG is related to the initial RNFL thickness, reduced arterial blood flow and choroid thinning.
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Authors:
N.I. Kurysheva
Oftal'mologicheskij tsentr Federal'nogo mediko-biologicheskogo agentstva, ul. Gamalei, 15, Moskva, Rossijskaja Federatsija, 123098
L.V. Lepeshkina
Ophthalmological Center of the Federal Medical-Biological Agency of the Russian Federation, A.I. Burnazyan Federal Medical and Biophysical Center of FMBA, 15 Gamalei St., Moscow, Russian Federation, 123098
E.O. Shatalova
Clinics of doctor ShatalovA Naberezhnaja St., Orekhovo-Zuyevo, Russia
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